Lauri A Aaltonen Selected Research

Hereditary leiomyomatosis and renal cell cancer

1/2022	Comparison of 2SC, AKR1B10, and FH Antibodies as Potential Biomarkers for FH-deficient Uterine Leiomyomas.
11/2021	Uterine leiomyomas in hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome can be identified through distinct clinical characteristics and typical morphology.
1/2016	MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas.
11/2013	MED12 exon 2 mutations in histopathological uterine leiomyoma variants.
9/2011	Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status.
6/2010	No evidence for a genetic modifier for renal cell cancer risk in HLRCC syndrome.
7/2009	Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditary leiomyomatosis and renal cell cancer.
9/2007	Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability.
5/2007	Conventional renal cancer in a patient with fumarate hydratase mutation.
7/2006	Analysis of fumarate hydratase mutations in a population-based series of early onset uterine leiomyosarcoma patients.

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Lauri A Aaltonen Research Topics

Disease

70	Neoplasms (Cancer) 01/2022 - 04/2002
34	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 02/2002
18	Leiomyoma (Uterine Fibroids) 01/2022 - 04/2002
14	Hereditary leiomyomatosis and renal cell cancer 01/2022 - 04/2005
12	Pituitary Neoplasms (Pituitary Adenoma) 12/2019 - 05/2006
9	Microsatellite Instability 09/2013 - 02/2002
7	Carcinogenesis 01/2021 - 01/2006
6	Colonic Neoplasms (Colon Cancer) 04/2012 - 11/2005
5	Renal Cell Carcinoma (Grawitz Tumor) 01/2022 - 08/2002
3	Genomic Instability 01/2018 - 09/2007
3	Leiomyomatosis 06/2012 - 04/2002
3	Hypoxia (Hypoxemia) 12/2009 - 01/2007
2	Genetic Predisposition to Disease (Genetic Predisposition) 11/2021 - 01/2016
2	Stomach Neoplasms (Stomach Cancer) 09/2015 - 06/2015
2	Peutz-Jeghers Syndrome (Polyposis, Hamartomatous Intestinal) 05/2013 - 09/2002
2	Kidney Neoplasms (Kidney Cancer) 09/2011 - 05/2007
2	Carcinoma (Carcinomatosis) 03/2009 - 05/2006
2	Polyps 11/2008 - 09/2002
2	Prostatic Neoplasms (Prostate Cancer) 09/2008 - 06/2006
2	Leiomyosarcoma 07/2006 - 01/2004
2	Hereditary Nonpolyposis Colorectal Neoplasms (Hereditary Nonpolyposis Colorectal Cancer) 05/2006 - 10/2005
1	Vascular Diseases (Vascular Disease) 10/2022
1	Disease Susceptibility (Diathesis) 10/2021
1	Cholelithiasis 01/2021
1	Inflammation (Inflammations) 01/2021
1	Gallstones (Gallstone) 01/2021
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2019
1	Atherosclerosis 01/2019
1	Adenocarcinoma of Lung 01/2018
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2018
1	Glioblastoma (Glioblastoma Multiforme) 10/2017
1	Disease Progression 01/2017
1	Genetic Risk Score 01/2017
1	Pediatric Obesity 07/2016
1	Dyskinesias (Dyskinesia) 01/2016
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2016

Drug/Important Bio-Agent (IBA)

23	Proteins (Proteins, Gene)FDA Link 12/2019 - 04/2002
19	Fumarate Hydratase (Fumarase)IBA 01/2022 - 04/2002
13	Calcibiotic Root Canal SealerIBA 01/2021 - 02/2002
9	aryl hydrocarbon receptor-interacting proteinIBA 04/2013 - 05/2006
8	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 08/2003
7	Mediator ComplexIBA 01/2017 - 10/2011
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 08/2002
5	Growth Hormone (Somatotropin)IBA 12/2019 - 05/2006
5	EnzymesIBA 09/2011 - 04/2002
4	RNA (Ribonucleic Acid)IBA 11/2021 - 08/2002
4	Messenger RNA (mRNA)IBA 01/2021 - 09/2005
4	Transcription Factors (Transcription Factor)IBA 01/2019 - 05/2008
4	NucleotidesIBA 01/2017 - 07/2007
4	Biological ProductsIBA 01/2016 - 10/2005
3	Formaldehyde (Formol)FDA Link 01/2022 - 07/2009
3	ParaffinIBA 01/2022 - 09/2005
3	Amino Acids FDA Link 12/2017 - 04/2002
3	FumaratesIBA 02/2016 - 01/2006
3	Transforming Growth Factor beta (TGF-beta)IBA 11/2008 - 04/2005
3	Phosphotransferases (Kinase)IBA 01/2006 - 06/2005
2	ChromatinIBA 01/2021 - 07/2015
2	RNA Polymerase II (RNA Polymerase B)IBA 01/2018 - 05/2014
2	Poly TIBA 09/2015 - 02/2011
2	Pharmaceutical PreparationsIBA 07/2013 - 03/2011
2	Aryl Hydrocarbon Receptor Nuclear TranslocatorIBA 10/2010 - 12/2009
2	Succinate Dehydrogenase (Fumarate Reductase)IBA 09/2007 - 01/2004
2	Codon (Codons)IBA 10/2005 - 11/2003
2	OligonucleotidesIBA 09/2005 - 08/2002
2	GuanineIBA 11/2003 - 02/2003
1	CollagenIBA 10/2022
1	Histone DemethylasesIBA 01/2022
1	AntibodiesIBA 01/2022
1	Apoptosis Regulatory ProteinsIBA 11/2021
1	BilirubinIBA 01/2021
1	25-hydroxyvitamin DIBA 01/2020
1	SeleniumIBA 01/2020
1	CalciumIBA 01/2020
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2020
1	colibactinIBA 01/2020
1	Exonucleases (3' 5' Exonuclease)IBA 01/2020
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 01/2020
1	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 01/2020
1	hydrogen sulfite (bisulfite)IBA 12/2019
1	CytokinesIBA 01/2019
1	Retroelements (Retrotransposon)IBA 01/2019
1	ChemokinesIBA 01/2019
1	telomerase RNA (bTR)IBA 01/2018
1	Membrane LipidsIBA 12/2017
1	LipidsIBA 12/2017
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 12/2017
1	Vitamin A (Retinol)FDA LinkGeneric 12/2017
1	homocarnosineIBA 12/2017
1	Dietary Fats (Dietary Fat)IBA 10/2017
1	Fatty Acids (Saturated Fatty Acids)IBA 10/2017
1	CholesterolIBA 01/2017
1	MucinsIBA 01/2017
1	Oxidoreductases (Dehydrogenase)IBA 01/2017
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2017
1	L-Aminoadipate-Semialdehyde DehydrogenaseIBA 01/2017
1	ORALIT (ORS)IBA 07/2016
1	Collagen Type IV (Type IV Collagen)IBA 02/2016

Therapy/Procedure

5	Therapeutics 10/2021 - 09/2005
4	Radiotherapy 10/2017 - 11/2009
4	Hysterectomy 01/2017 - 10/2009